Evaluation of teicoplanin and vancomycin disk susceptibility tests

Abstract

Disk tests with two glycopeptide antibiotics, teicoplanin and vanocomycin, were evaluated, and MICs were compared with those of fusidic acid and coumermycin.For tests with 30-.mu.g vancomycin disks, we recommend modification of the current zone size standards to .ltoreq. 10 mm for resistant and .gtoreq. 15 mm for susceptible. For teicoplanin disks tests, 30-.mu.g disks are recommended, with zone size interpretive standards of .ltoreq. 10 and .gtoreq. 14 mm. Since no resistant clinical isolates are available at this time, susceptibility testing of either drug is rarely necessary, and zone size standards are tentative.