Diagnosis of Erythrocyte Glucose-6-Phosphate Dehydrogenase Deficiency in the Negro Male Despite Hemolytic Crisis

Abstract

A simple procedure for the diagnosis of erythrocyte glucose-6-phosphate dehydrogenase deficiency in Negro males experiencing hemolytic crisis is described. By measuring enzyme activity in the persisting older erythrocytes, the deficiency can be recognized without having to wait until the hemolytic episode and its reticulocyte response have subsided.