Resuscitation with Pyridoxalated Stroma Free Hemoglobin

Abstract

The contribution of the RES in pyridoxalated stroma-free Hb (SFH-P) clearance may be insignificant. The magnitude of this is not at present clear. Any compromise of RES function would militate against its potential benefit as an O2-carrying resuscitation fluid. The relationship between lethal hemorrhage shock resuscitation with SFH-P and subsequent host depression was examined in a rat model. Host tolerance to a standard intra-abdominal polymicrobial septic challenge was assessed 5 days after hemorrhagic shock. Shock resuscitation with SFH-P Hb was equal to or better than all other resuscitation groups evaluated. Tolerance to a standard septic challenge 5 days after resuscitation was no different between resuscitation groups. There appears to be no compromise to host defense in general in tolerating intraabdominal sepsis 5 days following shock resuscitation with SFH-P.