Differential splicing in the 3′ non‐coding region of rat cytochrome P‐452 (P450 IVA1) mRNA
- 29 August 1988
- journal article
- Published by Wiley in FEBS Letters
- Vol. 236 (2), 357-361
- https://doi.org/10.1016/0014-5793(88)80055-3
Abstract
The gene coding for the clofibrate‐induced cytochrome P‐452 has been isolated from a cDNA library and a full‐length cDNA clone sequenced. The sequence was identical with that reported by Hardwick et al. [(1987) J. Biol. Chem. 262, 801–810] apart from the presence of an additional 75 nucleotides inserted adjacent to the 3′‐end of the coding region. Northern blot analysis indicates that this is probably a consequence of differential splicing, which may be relevant to the tissue‐specific regulation of this gene.Keywords
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