Radiotargeting agents for cancer therapy
- 4 November 2005
- journal article
- review article
- Published by Informa Healthcare in Expert Opinion on Drug Delivery
- Vol. 2 (6), 981-991
- https://doi.org/10.1517/17425247.2.6.981
Abstract
Although the general radiobiological principles underlying external beam therapy and radionuclide therapy are the same, there are significant differences in the radiobiological effects observed in mammalian cells. In external beam therapy and brachytherapy, emissions are composed of photons, whereas in radionuclide therapy, the radiations of interest are particulate. This article will explore the special features that characterise the biological effects consequent to the traversal of charged particles through mammalian cells. In addition, it will highlight what has been learned when these radionuclides and targeting radiopharmaceuticals are used to treat cancers.Keywords
This publication has 25 references indexed in Scilit:
- 131I-Tositumomab Therapy as Initial Treatment for Follicular LymphomaNew England Journal of Medicine, 2005
- Therapeutic potential of 5‐[125I]iodo‐2′‐deoxyuridine and methotrexate in the treatment of advanced neoplastic meningitisInternational Journal of Radiation Biology, 2004
- Tumor Therapy with Targeted Atomic NanogeneratorsScience, 2001
- In Vivo Therapy of Neoplastic Meningitis with Methotrexate and 5-[125I]iodo-2'-deoxyuridineActa Oncologica, 2000
- Cytotoxicity of [ 125 I]iodoHoechst 33342: contribution of scavengeable effectsInternational Journal of Radiation Biology, 1999
- Radioimmunotherapy of B-Cell Lymphoma with [131I]Anti-B1 (Anti-CD20) AntibodyNew England Journal of Medicine, 1993
- Radioimmunotherapy of athymic mice bearing human colon carcinomas with monoclonal antibody B72.3: Histological and autoradiographic study of effects on tumors and normal organsEuropean Journal of Cancer and Clinical Oncology, 1987
- The in Vitro Radiobiology of Astatine-211 DecayRadiation Research, 1986
- 5-125I-iododeoxyuridine as prototype for radionuclide therapy with Auger emittersNature, 1977
- The Radiotoxicity of Iodine-125 in Mammalian Cells: II. A Comparative Study on Cell Survival and Cytogenetic Responses to 125 IUdR, 131 IUdR, and 3 HTdRRadiation Research, 1976