In vitro Inhibition of Intestinal Fluid and Electrolyte Transfer by a Non-Beta Islet Cell Tumor
- 1 November 1966
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 123 (2), 361-364
- https://doi.org/10.3181/00379727-123-31488
Abstract
Summary Clinical observations in a patient with a non-Beta islet cell pancreatic adenocarcinoma demonstrated excessive fecal losses of fluid and electrolytes and excessive volumes of fluid from the distal ileum during continuous gastric aspiration. Intestinal transit time was normal. In vitro studies demonstrated the capacity of a distilled-water extract of an hepatic metastasis to inhibit the net mucosal-to-serosal transfer of fluid, sodium and chloride across everted gut sacs from the distal portion of the hamster small intestine. No effect of the tumor extract on in vitro intestinal motility was observed, These results suggest that the patient's diarrhea resulted from the tumor or its products inhibiting the net absorption of fluid and electrolytes in the patient's small intestine.This publication has 3 references indexed in Scilit:
- THE ACTION OF DRUGS ON THE CIRCULAR MUSCLE STRIP FROM THE GUINEA‐PIG ISOLATED ILEUMBritish Journal of Pharmacology and Chemotherapy, 1963
- Absorption by an in vitro preparation of dog intestinal mucosaJournal of Applied Physiology, 1963
- The use of sacs of everted small intestine for the study of the transference of substances from the mucosal to the serosal surfaceThe Journal of Physiology, 1954