Pseudomonas aeruginosa ExoT Is a Rho GTPase-Activating Protein
Open Access
- 1 October 2000
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 68 (10), 6066-6068
- https://doi.org/10.1128/iai.68.10.6066-6068.2000
Abstract
Transient intracellular expression of ExoT in CHO cells stimulated cell rounding and actin reorganization. Biochemical studies showed that ExoT was a GTPase-activating protein for RhoA, Rac1, and Cdc42. Together, these data show that ExoT interferes with Rho signal transduction pathways, which regulate actin organization, exocytosis, cell cycle progression, and phagocytosis.Keywords
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