Studies on the biological disposition of diethylstilbestrol in rats and humans
- 1 March 1976
- journal article
- Published by Taylor & Francis in Journal of Toxicology and Environmental Health
- Vol. 1 (4), 587-605
- https://doi.org/10.1080/15287397609529360
Abstract
Studies were conducted to elucidate the processes involved in the biological disposition of diethylstilbestrol (DES). The apparent biological half-life of [14C] DES decreased with increasing age in immature rats. The half-life of DES in adult rats (14 min) was reached between the 15th and 25th day after birth. Comparison of the intestinal absorption of [14C] DES and [14C]DES monoglucuronide showed the unconjugated drug to be absorbed much more rapidly. Hydrolysis of the conjugate took place in the lower intestine, and this permitted the drug to undergo enterohepatic cycling.Keywords
This publication has 22 references indexed in Scilit:
- The effect of altered hepatic function on the toxicity, plasma disappearance and biliary excretion of diethylstilbestrolToxicology and Applied Pharmacology, 1973
- Development in the Newborn Rat of the Conjugation and De-conjugation Processes Involved in the Enterohepatic Circulation of DiethylstilboestrolXenobiotica, 1972
- Effect of Age and Sex on Human Drug MetabolismBMJ, 1971
- Adenocarcinoma of the VaginaNew England Journal of Medicine, 1971
- Genetic Control of Drug Levels in Man: AntipyrineScience, 1968
- Genetic Control of Drug Levels in Man: PhenylbutazoneScience, 1968
- Extraction of steroid conjugates with a neutral resinSteroids, 1968
- INTESTINAL ABSORPTION OF BILE PIGMENTS. I. THE ENTEROHEPATIC CIRCULATION OF BILIRUBIN IN THE RAT*Journal of Clinical Investigation, 1963
- Glucuronide formation in the transport of thyroxine analogues by rat intestineBiochimica et Biophysica Acta, 1961
- Application of Buffered Solvent Systems to the Detection of Aromatic Acids by Paper Partition ChromatographyNature, 1951