Cloning of the Murine Thymic Stromal Lymphopoietin (Tslp) Receptor
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- 28 August 2000
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 192 (5), 659-670
- https://doi.org/10.1084/jem.192.5.659
Abstract
The cellular receptor for murine thymic stromal lymphopoietin (TSLP) was detected in a variety of murine, but not human myelomonocytic cell lines by radioligand binding. cDNA clones encoding the receptor were isolated from a murine T helper cell cDNA library. TSLP receptor (TSLPR) is a member of the hematopoietin receptor family. Transfection of TSLPR cDNA resulted in only low affinity binding. Cotransfection of the interleukin 7 (IL-7)Ralpha chain cDNA resulted in conversion to high affinity binding. TSLP did not activate cells from IL-7Ralpha(-/)- mice, but did activate cells from gammac(-/)- mice. Thus, the functional TSLPR requires the IL-7Ralpha chain, but not the gammac chain for signaling.Keywords
This publication has 45 references indexed in Scilit:
- Mouse macrophage development in the absence of the common γ chain: defining receptor complexes responsible for IL‐4 and IL‐13 signalingEuropean Journal of Immunology, 1997
- Common Cytokine Receptor γ chain (γc)‐Dependent Cytokines: Understanding in vivo Functions by Gene TargetingImmunological Reviews, 1995
- Chromosomal localization of a gene, GFI1 encoding a novel zinc finger protein reveals a new syntenic region between man and rodentsCytogenetic and Genome Research, 1995
- Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 ReceptorScience, 1993
- Cloning of the γ Chain of the Human IL-2 ReceptorScience, 1992
- RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangementCell, 1992
- Development and applications of a molecular genetic linkage map of the mouse genomeTrends in Genetics, 1991
- Development and applications of a molecular genetic linkage map of the mouse genomeTrends in Genetics, 1991
- Development of the mouse hematopoietic systemDevelopmental Biology, 1968
- THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONSAnnals of the New York Academy of Sciences, 1949