Forskolin activation of an identified peptide-sensitive motoneurone in Aplysia
Open Access
- 19 July 1983
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 79 (3), 631-633
- https://doi.org/10.1111/j.1476-5381.1983.tb09998.x
Abstract
Activation of a physiological response by the adenylate cyclase activator, forskolin, has been suggested as a new criterion for testing the role of cyclic AMP. In Aplysia, motoneurone B16, which innervates muscle 15, is activated by the peptide egg-laying hormone (ELH). In high magnesium-low calcium medium, used to block synaptic activity, forskolin produced a similar response to ELH. Forskolin, at a concentration of 100 μm, consistently activated the ELH-sensitive neurone; vehicle produced no response while 30 μm forskolin usually produced lower levels of activity than 100 μm. The data are consistent with cyclic AMP mediation of the ELH response.Keywords
This publication has 3 references indexed in Scilit:
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