Acute and chronic effects of domperidone on gastric emptying in diabetic autonomic neuropathy

Abstract
Gastric emptying was studied with a double radioisotopic method in 12 patients with insulin-dependent diabetes mellitus complicated by autonomic neuropathy and in 22 control subjects. In the diabetics, the acute and chronic effects of oral domperidone on gastric emptying, symptoms of gastroparesis, and glycemic control were assessed. Gastric emptying of solid and liquid was slower in diabetics than controls (PP0.05), but was still effective in increasing liquid emptying (PP<0.001).