Galactose-1-phosphate-uridyltransferase (E.C.2.7.7.11): A simple routine method for detecting individuals heterozygous for the silent allele Gt 0

Abstract

A simple routine method for detecting individuals who are heterozygous for the silent gene Gt⁰ is presented. This method consists of a combination of electrophoresis and densitometry. The results confirm the theoretical expectation that these individuals would exhibit about 50% of the enzyme activity found in the corresponding normal phenotype.