α-Lactalbumin-Casein Induction in Virgin Mouse Mammary Explants: Dose-Dependent Differential Action of Cortisol
- 21 March 1980
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 207 (4437), 1367-1369
- https://doi.org/10.1126/science.6986657
Abstract
The interplay of insulin, cortisol, and prolactin induces synthesis of casein and alpha-lactalbumin in cultured mammary explants from mature virgin mice. A striking difference has been found between the optimal concentrations of cortisol required for maximal induction of the two milk proteins in vitro: 3 x 10(-8) molar for alpha-lactalbumin and 3 x 10(-6) molar for casein. Moreover, 10(-7) to 10(-5) molar cortisol caused progressive inhibition of alpha-lactalbumin accumulation. Such differential actions of cortisol may partly account for the asynchronous synthesis of the two proteins during pregnancy.Keywords
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