A speculation on the origin of protein synthesis
- 1 December 1976
- journal article
- conference paper
- Published by Springer Nature in Origins of Life
- Vol. 7 (4), 389-397
- https://doi.org/10.1007/bf00927934
Abstract
It is suggested that protein synthesis may have begun without even a primitive ribosome if the primitive tRNA could take up two configurations and could bind to the messenger RNA with five base-pairs instead of the present three. This idea would impose base sequence restriction on the early messages and on the early genetic code such that the first four amino acids coded were glycine, serine, aspartic acid and aspargine. A possible mechanism is suggested for the polymerization of the early message.Keywords
This publication has 6 references indexed in Scilit:
- Molecular Mechanics of Translation : a Reciprocating Ratchet MechanismNature, 1970
- Evolution of the genetic apparatusJournal of Molecular Biology, 1968
- The origin of the genetic codeJournal of Molecular Biology, 1968
- Conformation of the Anticodon Loop in tRNANature, 1967
- Codon—anticodon pairing: The wobble hypothesisJournal of Molecular Biology, 1966
- CODES WITHOUT COMMASProceedings of the National Academy of Sciences, 1957