The Human Hemoglobins in Health and Disease

Abstract

Mixed Heterozygous Hemoglobin DiseasesTwo and possibly three hemolytic diseases are now recognized that fall into the group of mixed heterozygous hemoglobin diseases. The genetic mechanism involved in the heredity of this group is schematically portrayed in Figure 12. Each patient transmits the gene for a different hemoglobin. Some of the children of such a mating will therefore be heterozygous for each of the two abnormal hemoglobins.The most important disease in this group is sickle cell-Hgb G disease, in which the patient is heterozygous for Hgb S and Hgb C.^{8,11,56,76,78,79,92,94,105,106,110,180,206,213, 217} This disease waS first suspected in patients with atypical sickle-cell anemia . . .