Evaluation of 99mTc-labeled amino acids as radiopharmaceuticals. V. 99mTc complex of ethylenediamine-N,N-diacetic acid as a scintigraphic agent for tumors.

Abstract

Tumor tissues were clearly visualized in scintigrams of experimental animals bearing tumors a few hours after the administration of 99mTc complex of ethylenediamine-N,N-diacetic acid. The animals used were mice bearing Ehrlich tumor, mice bearing Sarcoma 180, golden hamsters bearing lymphoma, mice bearing fibrosarcoma induced by 3-methylcholanthrene (MC), rats bearing MC-induced fibrosarcoma that had been transplanted at the limb and had spontaneously metastasized to the lung, and mice bearing spontaneous mammary carcinoma. In the mice bearing Ehrlich tumor, the ratios of radioactivity, tumor/blood and tumor/muscle, were 3.32 and 7.96, respectively, at 3 h after the administration.