Vitamin D's: More and More Measured Better and Better

Abstract

Approximately 12 years ago, the development of radioactive vitamin D compounds of suitable specific activity prompted many investigations that enhanced understanding of the metabolism of vitamin D₂ (ergocalciferol) and D₃ (cholecalciferol) — hereafter designated vitamin D.¹ This technology, and improved chromatographic methods, also provided the tools for the creation and use of competitive protein-binding assays for the vitamin D sterols. As delineated by Haussler and McCain in the current Medical Progress section of the Journal there has been a recent explosion of information concerning the metabolism and mechanism of action of anti-rachitic sterols. Recent investigations of clinical effects . . .