The drug 3-ortho-toloxy-1,2-propanediol (myanesin,® tolserol®)1was introduced by Berger and Bradley2as a muscle-relaxing agent; it apparently raises the threshold of internuncial neurons in the spinal cord and brain stem.3Myanesin® does not affect voluntary muscle power, is not hypnotic and has negligible effects on the electroencephalogram in doses of 0.5 to 2.0 Gm. given by mouth four to five times a day. It has been used to alleviate spasticity and rigidity with variable results.4It has also been tried in cases of intractable pain5and in 3 psychotic patients.5b Its use in the treatment of anxiety was suggested to us by Dr. Pauline Cooke of Chicago. Sixty-three patients (from Manteno State Hospital) were chosen to test its effects not only in anxiety states but also in acute and chronic psychoses (mixed types of schizophrenia), in alcoholism, in addiction to drugs and as an