DISTRIBUTION OF ADRENO-GORTICAL (‘AC’) HORMONES IN TISSUES OF THE RAT UNDER NORMAL AND EXPERIMENTAL CONDITIONS1

Abstract

A method for the quantitative chemical assay of adreno-cortical (AC) hormones in tissues and of their qualitative composition is described. Considerable amts. of AC were found in muscle, kidney, brain, liver and spleen of the rat. Seasonal and racial variations and characteristic reactions to exptl. conditions, such as adm. of hormones (adrenalin, desoxycorticosterone, testosterone, insulin, thyroxin), adrenalectomy, castration, physical exercise, exposure to cold and warm temps., are discussed. The spleen seems to possess a special function as a storage and supply organ for AC reserves.