CHEMICAL STUDIES OF SEVERAL VARIETIES OF HB M
- 1 November 1961
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 47 (11), 1758-1767
- https://doi.org/10.1073/pnas.47.11.1758
Abstract
Five different varieties of abnormal hemoglobin of the Hb M group have been examined and an amino acid sequence alteration detected in four. The anomalous spectroscopic behavior of the Hbs M could be explained by assuming the existence of a new reactive side group capable of complexing with the heme iron. The new substituents observed all have the necessary properties to form such an internal complex.Keywords
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