STRUCTURE AND CHEMICAL SYNTHESIS OF ME-IQ, A POTENT MUTAGEN ISOLATED FROM BROILED FISH
- 5 November 1980
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 9 (11), 1391-1394
- https://doi.org/10.1246/cl.1980.1391
Abstract
Structure of a mutagenic compound (Me-IQ) isolated from broiled fish was determined to be 2-amino-3,4-dimethylimidazo[4,5-f]quinoline based on the mass-, UV- and 1H-NMR-spectra and chemical synthesis. Me-IQ showed strong mutagenic activity towards Salmonella typhimurium TA98 in the presence of S-9 mix.Keywords
This publication has 3 references indexed in Scilit:
- Formation of mutagens in cooked foods. III. Isolation of a potent mutagen from beefCancer Letters, 1980
- Potent novel mutagens produced by broiling fish under normal conditions.Proceedings of the Japan Academy, Series B, 1980
- Chemical synthesis of 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ), a potent mutagen isolated from broiled fish.Proceedings of the Japan Academy, Series B, 1980