Molecular recognition and catalysis; acceleration of acyl transfer reactions by a hydrogen-bonding receptor

1 January 1990

journal article
research article
Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications

No. 18,p. 1232-1234
https://doi.org/10.1039/c39900001232

Abstract

A hydrogen-bonding receptor containing an appended thiol has been synthesized and shown to cause large rate accelerations (k_obs/k_uncat > 10⁴) in the thiolysis reaction of complementary barbiturate acetate derivatives.

Keywords

ACCELERATION
HYDROGEN BONDING
BONDING RECEPTOR
ACYL
THIOLYSIS
BARBITURATE
KOBS/KUNCAT
ACETATE
APPENDED

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