Genomic imprinting: normal complementation of murine chromosome 16

Abstract

Summary: Parental imprinting effects for chromosome 16 were investigated using disomic animals which were obtained by mating (Rb32Lub × Rb2H) F1 mice. Two allelic forms of the enzyme CuZn-superoxide dismutase, Sod-1^a and Sod-1^c, were` used to identify maternally or paternally disomic animals. Both types of disomic animals were found with the expected frequencies and did not visibly differ from one another or from non-disomic animals. These results indicate that the genomic imprinting mechanism either does not act on chromosome 16, or, if it does, does not do so in a manner which affects normal development.