Plasma Glucagon Levels in Exercising Man

Abstract

THE hyperglycemic, glycogenolytic and gluconeogenic actions of glucagon have been recognized for some time.¹ The physiologic importance of this hormone, however, has only recently been substantiated with the evidence of increased circulating levels of glucagon during starvation² and after protein³ and amino acid administration.⁴ In the present study the spectrum of alpha-cell function was further extended with the demonstration of increased levels of pancreatic glucagon in association with physical exertion.MethodsSeven non-obese, healthy adult male volunteers were studied in the postabsorptive state, after an overnight fast of 12 to 14 hours. Single-leg exercise was performed in the sitting position . . .