THE EFFECT OF CORTISONE IN GUINEA-PIGS
- 1 July 1954
- journal article
- research article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 11 (1), 83-88
- https://doi.org/10.1677/joe.0.0110083
Abstract
SUMMARY: 1. The influence of cortisone and ascorbic acid on the course of experimentally induced scurvy in guinea-pigs has been studied. 2. The effect of cortisone varied with the intake of ascorbic acid. Cortisone neither accelerated nor retarded the development of scurvy in chronically scorbutic animals. When the intake of ascorbic acid was very low, cortisone did not prevent a fall in body weight and ultimate death from chronic scurvy. With a slightly higher (intermediate) dosage of ascorbic acid cortisone appeared to improve the retarded formation of epiphysial bone. With both intermediate and high intakes of synthetic ascorbic acid cortisone exerted a 'toxic' effect which ultimately resulted in earlier death. 3. Cortisone did not produce inhibition of wound healing in guinea-pigs.Keywords
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