Recurrent pseudomembranous colitis unassociated with prior antibiotic therapy

Abstract

• Fulminant and recurring pseudomembranous colitis developed in an elderly woman without prior antibiotic administration within the previous year. Stool culture yieldedClostridium difficile, and tissue cultures showedC difficilecytotoxin. Treatment with vancomycin hydrochloride was initially successful, but a serious relapse after its discontinuation necessitated low-dose long-term prophylaxis.Clostridium difficilemay be responsible for pseudomembranous colitis unassociated with antibiotic therapy. (Arch Intern Med1981;141:663-664)