Natural Killer and T‐Cell Potentiation by Monoclonal IgG against Natural Killer Cell FcR(IgG) or the T3 Complex
- 29 June 1986
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 23 (6), 639-645
- https://doi.org/10.1111/j.1365-3083.1986.tb01999.x
Abstract
Treatment of human natural killer (NK) cells with monoclonal antibodies of the IgG isotype against NK cell-FcR (IgG) increased lysis of most haematopoietic target cell lines with high or intermediate background NK susceptibility. Treatment of normal non-adhrent lymphocytes with an IgG antibody also increased lysis against the same target cells. Potentiating anti-FcR antibodies rapidly modulated FcR activity and the capacity of the cells to act as antibody-dependent killers, although such antibodies were demonstrable for a long time at the cell surface. Anti-FcR treatment did not influence concanavalin A (Con A)-dependent killing, in contrast to anti-T3 treatment, which suppressed lectin-dependent lysis but did not influence antibody-dependent killing. The data is compatible with a pro-receptor theory for FcR in NK killing, stating that such receptors may function in the same way as the T3 complex interacts with specific T cell receptors.This publication has 29 references indexed in Scilit:
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