LEAD IONS AND SYNAPTIC TRANSMISSION IN THE SUPERIOR CERVICAL GANGLION OF THE CAT
Open Access
- 1 June 1957
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 12 (2), 219-222
- https://doi.org/10.1111/j.1476-5381.1957.tb00123.x
Abstract
The perfused superior cervical ganglion of the cat has been used to study the effect of lead ions on synaptic transmission and on the relase of acetylcholine from preganglionic nerve endings. Lead ions, in concentrations of 5 to 40 μM./l., caused block of ganglionic transmission, and reduced the output of acetylcholine. Calcium ions (10 mM./l.) relieved the block produced by lead ions and restored the acetylcholine output. The presence of lead ions does not seem to change the sensitivity of ganglion cells to injected acetylcholine.Keywords
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