Genetic Regulation of Multiple Forms of Tyrosinase in Mice: Action of a and b Loci.

Abstract

Extensive allelic substitutions at the a and b loci in mice reveal that multiple forms of tyrosinase separable by acrylamide-gel electrophoresis are subject to complex genetic control. Depending upon genic constitution at the a and b loci, a maximum of 3 electrophoretically separable forms of tyrosinase are demonstrable. Specific alleles at these loci have also been shown to influence tyrosinase activity.