Absorption and Urinary Excretion of Quercetin, Rutin, and αG-Rutin, a Water Soluble Flavonoid, in Rats
- 28 March 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Agricultural and Food Chemistry
- Vol. 51 (9), 2785-2789
- https://doi.org/10.1021/jf026108a
Abstract
Quercetin, rutin, αG-rutin (a water soluble flavonoid), and a mixture of rutin and αG-rutin were administered to rats by a single gastric intubation, and their absorption and urinary excretion were examined. The plasma and 24 h urinary levels of aglycons (quercetin and tamarixetin/isorhamnetin) were measured by HPLC after deconjugation with β-glucuronidase/sulfatase treatment. αG-rutin was absorbed more rapidly than quercetin or rutin, and the plasma concentrations of quercetin and tamarixetin/isorhamnetin reached the highest peak level 30 min after dosing. Quercetin, rutin, and the mixture of rutin and αG-rutin showed the first peak level 8 h, 8 h, and 30 min after dosing, respectively. The area under the concentration−time curve (AUC) for quercetin in rats administered αG-rutin was approximately 4.5- and 2-fold higher than those in rats administered quercetin and rutin, respectively, and was almost the same as that in rats administered a mixture of rutin and αG-rutin. The highest 24 h urinary excretion was observed in αG-rutin-administered rats. These results suggest that αG-rutin is absorbed more efficiently than either quercetin or rutin and that a high plasma concentration can be maintained by supplying rutin and αG-rutin in combination. Keywords: Quercetin; rutin; αG-rutin; urinary excretion; absorption; AUCKeywords
This publication has 18 references indexed in Scilit:
- Efficiency of Absorption and Metabolic Conversion of Quercetin and Its Glucosides in Human Intestinal Cell Line Caco-2Archives of Biochemistry and Biophysics, 2000
- Plant polyphenols in cancer and heart disease: implications as nutritional antioxidantsNutrition Research Reviews, 2000
- Quercetin 3-O-β-glucoside is better absorbed than other quercetin forms and is not present in rat plasmaFree Radical Research, 2000
- Quercetin's Solubility Affects Its Accumulation in Rat Plasma after Oral AdministrationJournal of Agricultural and Food Chemistry, 1998
- Protection by αG‐Rutin, a Water‐soluble Antioxidant Flavonoid, against Renal Damage in Mice Treated with Ferric NitrilotriacetateJapanese Journal of Cancer Research, 1997
- Dietary quercetin is recovered in rat plasma as conjugated derivatives of isorhamnetin and quercetinThe Journal of Nutritional Biochemistry, 1996
- Inhibition of platelet aggregation by some flavonoidsThrombosis Research, 1991
- Flavonoids inhibit the oxidative modification of low density lipoproteins by macrophagesBiochemical Pharmacology, 1990
- Sequential enzymic hydrolysis of potentially aromatic glycosides from grapeCarbohydrate Research, 1988
- Studies on Drug Metabolism by Use of Isotopes XXVII: Urinary Metabolites of Rutin in Rats and the Role of Intestinal Microflora in the Metabolism of RutinJournal of Pharmaceutical Sciences, 1983