Retardation of Growth of Walker Rat Carcinoma 256 by Administration of Diethyl Riboflavin.

Abstract

Young, 31-45 g. male Sprague-Dawley rats in which Walker carcinoma 256 transplants were made showed, after 21 days, an 8 g. greater retention of their carcass tissue when receiving 30 [mu] g. diethylriboflavin than pair fed controls receiving an equimolar amt. of riboflavin. The avg. tumor size, expressed as % total body wt., of the diethylriboflavin group was 20% while the avg. tumor size of the riboflavin group was 30%, indicating a 33% inhibition of the growth of the tumors due to the admn. of diethylriboflavin.