Asthma genetics 2006: the long and winding road to gene discovery
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Open Access
- 5 January 2006
- journal article
- review article
- Published by Springer Nature in Genes & Immunity
- Vol. 7 (2), 95-100
- https://doi.org/10.1038/sj.gene.6364284
Abstract
Asthma and atopy are complex phenotypes that are influenced by both genetic and environmental factors. A review of nearly 500 papers on disease association studies identified 25 genes that have been associated with an asthma or atopy phenotype in six or more populations. An additional 54 genes have been associated in 2–5 populations. Here, we discuss the methods that have been used to identify susceptibility genes for common diseases and overview the status of asthma genetic research. Finally, current challenges and future directions are discussed.Keywords
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