INVITRO INDUCTION OF TUMOR-SPECIFIC IMMUNITY .3. LACK OF REQUIREMENT FOR H-2 COMPATIBILITY IN LYSIS OF TUMOR TARGETS BY T CELLS ACTIVATED INVITRO TO ONCOFETAL AND PLASMACYTOMA ANTIGENS

Abstract

Recent studies demonstrated that cytotoxic [mouse] T [thymus-derived] lymphocytes (CL), activated to various antigens other than those of the H-2 complex, will lyse target cells only when H-2 compatibility exists between the CL and target cell. T lymphocytes may only be capable of responding to H-2 antigen or antigens that become associated with H-2 region gene products. The data presented her suggest that (in some situations) cytotoxic T lymphocytes can specifically lyse target cells of different H-2 types. Two in vitro systems are described where primary induction of cytotoxic T lymphocytes to oncofetal and plasmacytoma antigens results in CL capable of lysing suitable targets bearing these antigens, of syngeneic or allogeneic derivation. Although interaction antigens involving H-2 components may preferentially activate T lymphocytes, this apparently does not imply a restriction on the recognition potential of T lymphocytes.