A Regulatory Locus for Mouse β-Glucuronidase Induction, Gur , Controls Messenger RNA Activity
- 9 February 1979
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 203 (4380), 554-556
- https://doi.org/10.1126/science.760204
Abstract
A regulatory locus in a higher organism has been shown to control a specific messenger RNA activity. The Gur locus in mice regulates the production of kidney beta-glucuronidase messenger RNA activity after induction of the beta-glucuronidase structural gene, Gus, by testosterone. beta-Glucuronidase messenger RNA was assayed by its ability to direct the synthesis of catalytically active murine beta-glucuronidase in Xenopus oocytes.Keywords
This publication has 13 references indexed in Scilit:
- Segregation of genetic determinants for murine glucuroinidase synthesis and loss in CXB recombinant-inbred strainsBiochemical Genetics, 1978
- Regulation of Hemoglobin Synthesis during the Development of the Red CellNew England Journal of Medicine, 1977
- Protein synthesis in oocytes of xenopus laevis is not regulated by the supply of messenger RNACell, 1977
- Direct demonstration of β-globin mRNA in homozygous Ferrara β0-thalassaemia patientsNature, 1977
- Absence of messenger RNA and gene DNA for β-globin chains in hereditary persistence of fetal hemoglobinCell, 1976
- Enzyme InductionNew England Journal of Medicine, 1976
- Defective lysosomal enzyme secretion in kidneys of Chediak-Higashi (beige) mice.The Journal of cell biology, 1975
- Genetic control of glucuronidase induction in miceJournal of Molecular Biology, 1973
- Dual localization of acid hydrolases in endoplasmic reticulum and in lysosomesHistochemistry and Cell Biology, 1969
- [103a] The use of guanidinium chloride in the isolation of nucleic acidsMethods in Enzymology, 1968