The Disposition of Orally Administered Cholestyramine-C14

Abstract

Summary Groups of rats were given a single large dose, or repeated smaller doses of cholestyramine labeled in the carbon skeleton with C¹⁴. No radioactivity could be detected in the blood, liver, kidneys or respiratory CO₂ of these animals. Significant amounts of radioactivity were found only in feces and in the gastrointestinal tract, indicating that cholestyramine is not absorbed from the gastrointestinal tract of the rat.