Inhibition by γ‐hydroxybutyrate of chlorpromazine‐induced increase in homovanillic acid
Open Access
- 1 February 1973
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 47 (2), 408-414
- https://doi.org/10.1111/j.1476-5381.1973.tb08338.x
Abstract
1 γ-Hydroxybutyrate and its lactone precursor, γ-butyrolactone, when administered in anaesthetic doses block the increase in the cerebral concentration of homovanillic acid normally observed after administration of chlorpromazine or haloperidol. 2 Other hypnotics such as glutethimide, urethane, chloralose, chloral hydrate and thiopentone do not have this ability even when administered in anaesthetic doses. 3 The ability of γ-hydroxybutyrate to block the neuroleptic-induced increase in cerebral homovanillic acid is not due to a reduction in body temperature since a similar effect is observed in rats treated under conditions (32° C) in which body temperature remains normal. 4 Possible mechanisms for this action of γ-hydroxybutyrate are discussed.Keywords
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