AUTOTRANSPLANTATION OF THE ADRENAL OF THE RAT TO THE PORTAL CIRCULATION: EFFECT OF ADMINISTRATION OF SEX HORMONES1

Abstract

Extensive hypertrophy occurs in an adrenal gland transplanted to the portal circulation of the adrenalectomized female rat. This hypertrophy is prevented not only by oophorectomy, but also by the administration of testosterone. Ordinarily, this phenomenon does not occur in the male rat, but can be induced in this sex by the administration of estrogen. It is inferred that estrogen is essential for, and androgen is inhibitory to, the production of this unusual hypertrophy in the transplanted adrenal.