Distinct metaplastic and inflammatory phenotypes in autoimmune and adenocarcinoma‐associated chronic atrophic gastritis
Open Access
- 1 February 2017
- journal article
- research article
- Published by Wiley in United European Gastroenterology Journal
- Vol. 5 (1), 37-44
- https://doi.org/10.1177/2050640616644142
Abstract
Autoimmune gastritis (AIG) and adenocarcinoma-associated chronic atrophic gastritis (CAG) are both associated with oxyntic atrophy, but AIG patients demonstrate an increased risk of carcinoid tumors rather than the elevated risk of adenocarcinoma observed with CAG. We therefore sought to compare the characteristics of the metaplastic mucosa in AIG and CAG patients. We examined markers for metaplasia (spasmolytic polypeptide expressing metaplasia (SPEM) and intestinal metaplasia) as well as proliferation (Ki67) and immune cell populations (neutrophils, macrophages, and eosinophils) in gastric sections from 16 female patients with autoimmune thyroiditis and AIG and 17 patients with CAG associated with gastric adenocarcinoma. Both AIG and CAG patients demonstrated prominent SPEM and intestinal metaplasia. However, AIG patients displayed significantly lower numbers of infiltrating macrophages and significantly reduced mucosal cell proliferation as compared to CAG patients. These findings indicate that, while both AIG and CAG patients display prominent oxyntic atrophy and metaplasia, the AIG patients do not show proliferative metaplastic lineages that would predispose to adenocarcinoma.Keywords
Funding Information
- National Institutes of Health (RO1 DK071590, RO1 DK101332)
- T.J. Martell Foundation
- National Cancer Institute
This publication has 31 references indexed in Scilit:
- Autoimmune atrophic gastritis—pathogenesis, pathology and managementNature Reviews Gastroenterology & Hepatology, 2013
- Autoimmune Gastritis Mediated by CD4+ T Cells Promotes the Development of Gastric CancerCancer Research, 2013
- Autoimmune gastritis: novel clues to histological diagnosisPathology, 2013
- Proteomic Profiling of Paraffin-Embedded Samples Identifies Metaplasia-Specific and Early-Stage Gastric Cancer BiomarkersThe American Journal of Pathology, 2012
- Spasmolytic Polypeptide-Expressing Metaplasia and Intestinal Metaplasia: Time for Reevaluation of Metaplasias and the Origins of Gastric CancerGastroenterology, 2010
- CellProfiler: image analysis software for identifying and quantifying cell phenotypesGenome Biology, 2006
- Prevalence of Subtypes of Intestinal Metaplasia in the General Population and in Patients with Autoimmune Chronic Atrophic GastritisScandinavian Journal of Gastroenterology, 2002
- Intestinal metaplasia of the stomach. A status reportCancer, 1994
- A human model of gastric carcinogenesis.1988
- Gastric morphology and serum gastrin levels in pernicious anaemia.Gut, 1976