Oligoclonal Expansion and CD1 Recognition by Human Intestinal Intraepithelial Lymphocytes
- 20 September 1991
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 253 (5026), 1411-1415
- https://doi.org/10.1126/science.1716785
Abstract
A human intestinal intraepithelial lymphocyte (IEL) T cell line was established from jejunum to characterize the structure and function of the alpha beta T cell antigen receptors (TCRs) expressed by this population. Single-sided polymerase chain reaction (PCR) amplification cloning and quantitative PCR amplification of the TCR chains from the cell line and from fresh IELs demonstrated that IELs were oligoclonal. The IEL T cell line exhibited CD1-specific cytotoxicity and a dominant IEL T cell clone was CD1c-specific. Thus, human jejunal intraepithelial lymphocytes are oligoclonal and recognize members of the CD1 gene family.Keywords
This publication has 50 references indexed in Scilit:
- Shared Human T Cell Receptor V β Usage to Immunodominant Regions of Myelin Basic ProteinScience, 1990
- Frequency analysis of CD4+CD8+ T cells cloned with IL-4Cellular Immunology, 1990
- Homing of a γδ thymocyte subset with homogeneous T-cell receptors to mucosal epitheliaNature, 1990
- Recognition of cluster of differentiation 1 antigens by human CD4−CD8>− cytolytic T lymphocyteNature, 1989
- Specificity and function of T cells bearing γδ receptorsImmunology Today, 1988
- Intestinal intraepithelial lymphocytes are a distinct set of γδ T cellsNature, 1988
- Structure and specificity of T cell receptor gamma/delta on major histocompatibility complex antigen-specific CD3+, CD4-, CD8- T lymphocytes.The Journal of Experimental Medicine, 1988
- Expression of the γ-δ T-cell receptor on intestinal CD8+ intraepithelial lymphocytesNature, 1988
- Genes of the T-Cell Antigen Receptor in Normal and Malignant T CellsAnnual Review of Immunology, 1987
- Leukocytes in the intestinal epithelium: an unusual immunological compartmentImmunology Today, 1985