MODIFICATION OF THE BINDING-PROPERTIES OF MUSCARINIC RECEPTORS BY GALLAMINE
- 1 January 1983
- journal article
- research article
- Vol. 23 (3), 551-557
Abstract
The interaction of gallamine with [rat] muscarinic receptors from different tissues was investigated. Gallamine binds to a site distinct from the conventional muscarinic ligand binding site and modulates the binding of agonists and antagonists to the conventional binding site. The effects of gallamine on the binding of muscarinic ligands are much greater in heart than in other tissues. These findings suggest the possibility of developing novel and selective muscarinic drugs.This publication has 14 references indexed in Scilit:
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