Abstract
Lenticular S-adenosylmethionine [Ado-Met] synthetase was partially purified and characterized. Lower levels of S-Ado-Met synthetase were detected by a sensitive radioactive assay procedure in the lenticular extract obtained from the pooled lenses of alloxan-treated rats 96 days of age as compared to the nontreated controls. With respect to chromatographic behavior and kinetic analysis, lenticular S-Ado-Met synthetase closely resembled that of the corresponding liver enzyme.