Rapid Determination of Quinidine in Human Plasma by High-Performance Liquid Chromatography
- 1 June 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Chromatographic Science
- Vol. 16 (6), 271-273
- https://doi.org/10.1093/chromsci/16.6.271
Abstract
A sensitive and specific method for the determination of quinidine in plasma is described. Quinidine is extracted with chloroform, the extract is evaporated and reconstituted with methanol and the methanol extract is analyzed by high-performance liquid chromatography using a silica gel column. The recovery of quinidine from plasma varied between 93.0 to 100%. Quinidine levels as low as 12 ng/ml can be detected by this method.This publication has 3 references indexed in Scilit:
- SPECIFIC DETERMINATION OF QUINIDINE AND (3S)-3-HYDROXYQUINIDINE IN HUMAN-SERUM BY HIGH-PRESSURE LIQUID-CHROMATOGRAPHY1977
- The separation of a wide range of drugs of abuse by high-pressure liquid chromatographyJournal of Chromatography A, 1975
- Quantitative Determination of Quinidine in PlasmaScandinavian Journal of Clinical and Laboratory Investigation, 1963