Increase in Tγ Lymphocytes in B‐Cell Chronic Lymphocytic Leukaemia
- 24 April 1980
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Haematology
- Vol. 24 (2), 187-190
- https://doi.org/10.1111/j.1600-0609.1980.tb02366.x
Abstract
A significant increase in the proportion (mean 38% .+-. 9.3) and absolute number of T [thymus-derived] (suppressor) lymphocytes was observed in 13 patients with chronic lymphocytic leukemia (CLL) compared with 20 normal controls (mean 19% .+-. 6.5). Conversely, the proportion of T.mu. (helper) lymphocytes was lower in CLL (mean 27% .+-. 9.3) than in the controls (mean 40% .+-. 4), although the absolute numbers were normal or increased. An imbalance of T lymphocyte subsets controlling B [bone marrow-derived] lymphocyte differentiation may be relevant in the pathogenesis of CLL or some of its associated features.Keywords
This publication has 17 references indexed in Scilit:
- Disorders of Suppressor Immunoregulatory Cells in the Pathogenesis of Immunodeficiency and AutoimmunityAnnals of Internal Medicine, 1978
- Imbalances in T cell subpopulations associated with immunodeficiency and autoimmune syndromesEuropean Journal of Immunology, 1977
- A clinical staging system for chronic lymphocytic leukemia.Prognostic significanceCancer, 1977
- The Immunological Diagnosis of Human Leukemias and Lymphomas: an OverviewHaematology and Blood Transfusion Hämatologie und Bluttransfusion, 1977
- Expression of a receptor for IgM by human T cells in vitroEuropean Journal of Immunology, 1975
- B-CELL NEOPLASIA IN MANThe Lancet, 1974
- CLINICAL SIGNIFICANCE OF T-CELLS IN CHRONIC LYMPHOCYTIC LEUKAEMIAThe Lancet, 1974
- LOSS OF SUPPRESSOR FUNCTION AS A CAUSE OF LYMPHOID MALIGNANCYThe Lancet, 1973
- ISOLATION OF NORMAL T CELLS IN CHRONIC LYMPHATIC LEUKÆMIAThe Lancet, 1973
- Clinical Correlations with Immunoglobulin Levels in Chronic Lymphatic Leukaemia§Australian and New Zealand Journal of Medicine, 1972