Leukocytic and Pyrogenic Effects of Typhoid Vaccine and Augmentation by Homologous Plasma

Abstract

The response of the temp. and the leukocyte count of the rabbit to intraven. administered typhoid vaccine was dependent on the amt. of typhoid vaccine given. Small amts. caused little or no fever, a heterophile leukocytosis, and a mononuclear leukopenia. When larger doses were given, the rabbits responded with high fever, an initial heterophile leukopenia followed by a secondary leukocytosis, and a sustained mononuclear leukopenia. Ten times as many organisms were required in saline suspensions to produce a thermogenic and leukocytic response comparable to that produced when the vaccine was given in homologous plasma. The plasma-typhoid and saline-typhoid reaction differed only in degree, except for the earlier onset of fever when the organisms were given in plasma.