Tamoxifen Induces Heparanase Expression in Estrogen Receptor–Positive Breast Cancer
Open Access
- 15 July 2007
- journal article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 13 (14), 4069-4077
- https://doi.org/10.1158/1078-0432.ccr-06-2546
Abstract
Purpose: Mammalian heparanase degrades heparan sulfate, the main polysaccharide of the basement membrane. Heparanase is an important determinant in cancer progression, acting via the breakdown of extracellular barriers for invasion, as well as release of heparan sulfate–bound angiogenic and growth-promoting factors. The present study was undertaken to elucidate molecular mechanisms responsible for heparanase overexpression in breast cancer.Keywords
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