The Kinetics of Streptomycin, Kanamycin and Neomycin in the Inner Ear

Abstract

The levels of streptomycin, kanamycin and neomycin in inner ear fluid were determined. These antibiotics penetrate into the inner ear slowly and relatively in small amounts and are eliminated more slowly than from the blood. The most slow to be eliminated is neomycin and therefore after repeated daily doses there is regularly some cumulation. In cases of the middle ear otitis concentration of antibiotics in the inner ear is multiplied.