Bisphosphonates: Molecular Modelling, Structure-Activity Relationships and the Rational Design of New Analogs
- 1 March 1993
- journal article
- research article
- Published by Taylor & Francis in Phosphorus, Sulfur, and Silicon and the Related Elements
- Vol. 76 (1), 151-154
- https://doi.org/10.1080/10426509308032381
Abstract
A combination of 2D NMR spectroscopy, x-ray crystallography and molecular mechanics have been used in the structure determination of a conformationally rigid antiresorptive active bisphosphonate. This rigid structure has provided a template from which other conformationally restricted actives have been successfully designed.Keywords
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