ADRENAL ESTROGENS. I. CONVERSION OF 4-C14-CORTISONE ACETATE TO 11-OXYGENATED ESTROGENS IN WOMEN
- 1 June 1961
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 21 (6), 624-634
- https://doi.org/10.1210/jcem-21-6-624
Abstract
The bioconversion of adrenal corticosteroids to phenolic estrogens was investigated. After the administration of 4-C14-cortisone acetate to a castrated and adrenalectomized woman with breast cancer, 11β-hydroxyestrone and 11β-hydroxyestradiol were isolated from the urine. The radiochemical purity and identity of the C14-labeled conversion products were ascertained by paper chromatography, counter-current distribution, and carrier crystallization. After administration of 4-C14-cortisol to the. same patient, however, this conversion did not occur.Keywords
This publication has 8 references indexed in Scilit:
- ESTROGEN EXCRETION IN OVARIEOTOMIZED WOMEN RECEIVING ADRENOCORTICOTROPIN*†Journal of Clinical Endocrinology & Metabolism, 1958
- ADRENAL ESTROGENS IN PATIENTS WITH METASTATIC BREAST CANCER1JCI Insight, 1958
- CONVERSION OF TESTOSTERONE TO ESTROGENS IN CASTRATED, ADRENALECTOMIZED HUMAN FEMALESJournal of Biological Chemistry, 1956
- CONVERSION OF TESTOSTERONE-3-C-14 TO C-14-ESTRADIOL-17 BETA BY HUMAN OVARIAN TISSUE1956
- An improved method of gradient elution chromatography and its application to the separation of urinary ketosteroidsArchives of Biochemistry and Biophysics, 1954
- THE IN VIVO METABOLISM OF CORTISONE1Endocrinology, 1953
- Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissuesBiochemical Journal, 1952
- FLUORESCENCE SPECTRA OF NATURAL ESTROGENS AND THEIR APPLICATION TO BIOLOGICAL EXTRACTSEndocrinology, 1950