Steric course of the 3-hydroxy-3-methylglutaryl CoA reductase reaction

1 January 1970

journal article
research article
Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society D: Chemical Communications

No. 21,p. 1394a
https://doi.org/10.1039/c2970001394a

Abstract

Reduction of the hemithioacetal from coenzyme A and (±)-mevaldic acid with (4R)-[4-³H]-NADPH in the presence of 3-hydroxy-3-methylglutaryl CoA reductase from yeast gives (3R,5S)-[5-³H]-mevalonic acid.

Keywords

STERIC COURSE
HYDROXY
METHYLGLUTARYL
REDUCTASE REACTION
REACTION REDUCTION
MEVALONIC ACID
MEVALDIC ACID
HEMITHIOACETAL

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