Novel Protein Kinases Ark1p and Prk1p Associate with and Regulate the Cortical Actin Cytoskeleton in Budding Yeast
Open Access
- 22 March 1999
- journal article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 144 (6), 1203-1218
- https://doi.org/10.1083/jcb.144.6.1203
Abstract
Ark1p (actin regulating kinase 1) was identified as a yeast protein that binds to Sla2p, an evolutionarily conserved cortical actin cytoskeleton protein. Ark1p and a second yeast protein, Prk1p, contain NH2-terminal kinase domains that are 70% identical. Together with six other putative kinases from a number of organisms, these proteins define a new protein kinase family that we have named the Ark family.Keywords
This publication has 63 references indexed in Scilit:
- Pan1p, Yeast eps15, Functions as a Multivalent Adaptor That Coordinates Protein–Protein Interactions Essential for EndocytosisThe Journal of cell biology, 1998
- Structure, Expression, and Chromosomal Localization of Human GAKGenomics, 1997
- Emerging from the Pak: the p21-activated protein kinase familyTrends in Cell Biology, 1997
- ACTIN: General Principles from Studies in YeastAnnual Review of Cell and Developmental Biology, 1996
- CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choiceNucleic Acids Research, 1994
- Synthetic-lethal interactions identify two novel genes, SLA1 and SLA2, that control membrane cytoskeleton assembly in Saccharomyces cerevisiaeThe Journal of cell biology, 1993
- The small GTP-binding protein rac regulates growth factor-induced membrane rufflingCell, 1992
- The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factorsCell, 1992
- Basic local alignment search toolJournal of Molecular Biology, 1990
- Confidence Limits on Phylogenies: An Approach Using the BootstrapEvolution, 1985